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Current animal models testing hydrogel-based brachytherapy Preclinical investigations in rodent and larger animal models have established the safety and multifunctional potential of hydrogel-assisted brachytherapy, demonstrating consistent organ-at-risk separation and reduced radiation injury to the bladder, rectum, and bowel [177, 178]

This bidirectional regulation suggests sophisticated sensing of tissue microenvironmental cues, enabling GHK-Cu to normalize MMP activity toward homeostatic levels rather than exerting uniform stimulatory or inhibitory effects

Guidelines of prevention and treatment of nonalcoholic fatty liver disease (2018, China)